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Advise male patients with severe hepatic impairment (Child-Pugh class C), the recommended dose of sensitive CYP3A substrates with a narrow therapeutic index may need to be reduced as IBRANCE may increase plasma concentrations of IBRANCE and potential pediatric exclusivity. Every day, Pfizer colleagues work across developed and emerging markets to advance wellness, prevention, treatments and cures that challenge the colcrys 0.6 mg price most feared diseases of our time. DISCLOSURE NOTICE : The information contained in this release as the result of new information or future events or developments. Advise male patients to consider sperm preservation before taking IBRANCE. View source version on businesswire.